配体发现的模块化方法。
The modular approach to ligand discovery.
作者信息
Karan Charles, Tallarico John A
机构信息
Harvard Institute of Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, Room 622, Boston, MA 02115, USA.
出版信息
Chem Biol. 2004 Mar;11(3):292-3. doi: 10.1016/j.chembiol.2004.03.002.
Abstract
Identifying specific protein-ligand interactions is a long-standing problem in drug discovery and chemical biology, which is only exacerbated by the abundance of uncharacterized proteins revealed by genomics. Last month in Chemistry Biology, Sem et al. described a powerful technique for rapidly screening protein families for ligands.
摘要
识别特定的蛋白质-配体相互作用是药物研发和化学生物学领域长期存在的问题，而基因组学揭示的大量未表征蛋白质更是加剧了这一问题。上个月，Sem等人在《化学生物学》杂志上描述了一种用于快速筛选蛋白质家族配体的强大技术。
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