Carter Christy S, Cesari Matteo, Ambrosius Walter T, Hu Nan, Diz Debra, Oden Sherry, Sonntag William E, Pahor Marco
Sticht Center on Aging, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
J Gerontol A Biol Sci Med Sci. 2004 May;59(5):416-23. doi: 10.1093/gerona/59.5.b416.
This study was designed to test the effects of angiotensin-converting enzyme (ACE) inhibition on body composition and physical performance in aged rats. Male Brown Norway x F344 rats were randomized to receive daily injections of enalapril (40 mg/kg or 80 mg/kg) or saline from 24 to 30 months of age. Body composition was determined using dual-energy X-ray absorptiometry (DXA), and physical performance was assessed using the grip strength and inclined plane procedures. Performance measures were assessed at baseline and monthly thereafter. DXA was performed at baseline, 3 months, and 6 months of follow-up. Compared with the enalapril groups, the saline group experienced a greater 6-month decline in the physical performance measures. Lean body mass declined in both groups; however, the enalapril groups also experienced a significant loss of fat mass. These results suggest that ACE inhibition may prevent age-related declines in physical performance, which may be mediated by a reduction in body fat mass.
本研究旨在测试血管紧张素转换酶（ACE）抑制对老年大鼠身体成分和身体机能的影响。将雄性挪威棕鼠×F344大鼠随机分为两组，从24月龄至30月龄每日分别注射依那普利（40mg/kg或80mg/kg）或生理盐水。使用双能X线吸收法（DXA）测定身体成分，使用握力和斜面试验评估身体机能。在基线期及之后每月评估一次性能指标。在基线期、随访3个月和6个月时进行DXA检查。与依那普利组相比，生理盐水组在身体机能指标方面6个月的下降幅度更大。两组的去脂体重均下降；然而，依那普利组的脂肪量也出现了显著减少。这些结果表明，ACE抑制可能预防与年龄相关的身体机能下降，这可能是通过减少身体脂肪量来介导的。
