数量性状基因座连锁不平衡精细定位方法之间的比较。

A comparison between methods for linkage disequilibrium fine mapping of quantitative trait loci.

作者信息

Abdallah Jihad M, Mangin Brigitte, Goffinet Bruno, Cierco-Ayrolles Christine, Pérez-Enciso Miguel

机构信息

Station d'amélioration génétique des animaux, Institut national de la recherche agronomique, Castanet-Tolosan, France.

出版信息

Genet Res. 2004 Feb;83(1):41-7. doi: 10.1017/s0016672303006554.

DOI:10.1017/s0016672303006554

PMID:15125065

Abstract

We present a maximum likelihood method for mapping quantitative trait loci that uses linkage disequilibrium information from single and multiple markers. We made paired comparisons between analyses using a single marker, two markers and six markers. We also compared the method to single marker regression analysis under several scenarios using simulated data. In general, our method outperformed regression (smaller mean square error and confidence intervals of location estimate) for quantitative trait loci with dominance effects. In addition, the method provides estimates of the frequency and additive and dominance effects of the quantitative trait locus.

摘要

我们提出了一种用于定位数量性状基因座的最大似然方法，该方法利用单个和多个标记的连锁不平衡信息。我们对使用单个标记、两个标记和六个标记的分析进行了成对比较。我们还在几种情况下使用模拟数据将该方法与单标记回归分析进行了比较。总体而言，对于具有显性效应的数量性状基因座，我们的方法优于回归分析（位置估计的均方误差和置信区间更小）。此外，该方法还能估计数量性状基因座的频率以及加性和显性效应。