Cheng Xiaoliang, Filiaggi Mark, Roscoe Sharon G
Department of Chemistry, Acadia University, 6 University Ave, Wolfville, Nova Scotia, Canada B4P 2R6.
Biomaterials. 2004 Oct;25(23):5395-403. doi: 10.1016/j.biomaterials.2003.12.045.
A bovine serum albumin protein-containing calcium phosphate coating (BSA/brushite) was prepared by electrochemically assisted co-precipitation onto a hydroxyapatite (HA) coated Ti-6Al-4V surface. Electrochemically assisted co-precipitation of BSA/brushite coatings onto HA resulted in a 70-fold increase in BSA inclusion compared to simple adsorption, and was subsequently released by a slower mechanism (15% loss over 70 h). Thus, this electrochemically assisted co-precipitation technique provides an efficient method of protein incorporation at physiological temperature, with a potential for sustained release of therapeutic agents as may be required for metallic implant fixation.
通过电化学辅助共沉淀法在羟基磷灰石（HA）涂层的Ti-6Al-4V表面制备了含牛血清白蛋白的磷酸钙涂层（BSA/透钙磷石）。与简单吸附相比，将BSA/透钙磷石涂层电化学辅助共沉淀到HA上使BSA的掺入量增加了70倍，随后以较慢的机制释放（70小时内损失15%）。因此，这种电化学辅助共沉淀技术提供了一种在生理温度下有效掺入蛋白质的方法，具有持续释放金属植入物固定所需治疗剂的潜力。
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