Russman Barry S, Ashwal Stephen
Department of Pediatrics and Neurology, Oregon Health Sciences University, Portland, OR, USA.
Semin Pediatr Neurol. 2004 Mar;11(1):47-57. doi: 10.1016/j.spen.2004.01.007.
Cerebral palsy (CP) is a common problem, occurring in about 2 to 2.5 per 1000 live births. The diagnosis of CP is based upon a history of abnormal motor development that is not progressive coupled with an examination (e.g. hypertonicity, increased reflexes, clonus) "placing" the lesion in the brain. In order to establish that a brain abnormality exists in children with CP that may, in turn, suggest an etiology and prognosis, neuroimaging is recommended with magnetic resonance imaging preferred to computed tomography. Metabolic and genetic studies should be obtained if there are atypical features in the history or on the examination. Detection of a brain malformation in a child with CP might suggest an underlying genetic or metabolic etiology. As cerebral infarction is high in children with hemiplegic CP, diagnostic testing for coagulation disorders should be considered. However, there is insufficient evidence at present to be precise as to what studies should be ordered. An electroencephalogram is not recommended unless there are features suggestive of epilepsy or a specific epileptic syndrome. As children with CP may have associated deficits of mental retardation, ophthalmologic and hearing impairments, speech and language disorders and oral-motor dysfunction, screening for these conditions should be part of the initial assessment.
脑瘫(CP)是一个常见问题,每1000例活产儿中约有2至2.5例发生。脑瘫的诊断基于非进行性异常运动发育史,并结合体格检查(如张力亢进、反射增强、阵挛)将病变“定位”在脑部。为了确定脑瘫患儿存在脑异常,进而提示病因和预后,建议进行神经影像学检查,首选磁共振成像而非计算机断层扫描。如果病史或体格检查中有非典型特征,则应进行代谢和基因研究。在脑瘫患儿中检测到脑畸形可能提示潜在的遗传或代谢病因。由于偏瘫型脑瘫患儿发生脑梗死的几率较高,应考虑进行凝血障碍的诊断性检查。然而,目前尚无足够证据明确应安排哪些检查。除非有提示癫痫或特定癫痫综合征的特征,否则不建议进行脑电图检查。由于脑瘫患儿可能伴有智力发育迟缓、眼科和听力障碍、言语和语言障碍以及口腔运动功能障碍,对这些情况的筛查应作为初始评估的一部分。