苯环上的形式自由基环化反应：一种通用方法及其在对映-诺卡酮A合成中的应用。
Formal radical cyclization onto benzene rings: a general method and its use in the synthesis of ent-nocardione A.
作者信息
Clive Derrick L J, Fletcher Stephen P, Liu Dazhan
机构信息
Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2.
出版信息
J Org Chem. 2004 May 14;69(10):3282-93. doi: 10.1021/jo030364k.
PMID:15132533
Abstract
An indirect method is described for effecting radical cyclization onto a benzene ring. Cross-conjugated dienones 6, which are readily prepared from phenols, undergo radical cyclization (6 --> 7 --> 8), and the products (8) are easily aromatized. The method has been applied to the synthesis of ent-nocardione A (21).
摘要
描述了一种用于在苯环上进行自由基环化的间接方法。由酚类容易制备的交叉共轭二烯酮6进行自由基环化（6→7→8），并且产物（8）易于芳构化。该方法已应用于对映-诺卡酮A（21）的合成。
Zotero 插件