Li Ji, Liu Hong-rui, Guo Li-na
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Zhonghua Bing Li Xue Za Zhi. 2004 Apr;33(2):109-12.
Morphologic findings of pulmonary Langerhans' cell histiocytosis were analyzed in order to delineate diagnostic features.
H&E staining and immunohistochemical studies were performed on 7 cases of pulmonary Langerhans' cell histiocytosis.
Infiltration by Langerhan's cells was obvious in all 7 cases. Inflammatory cell infiltrates, interstitial fibrosis and focal necrosis may also be seen. The cells expressed S-100 (7/7), CD68 (3/7), and CD1a (5/5).
In case there is radiologic suspicion of Langerhans' cell histiocytosis, pulmonary biopsy is strongly advised for a definitive diagnosis. S-100 and CD1a immunostaining is also helpful in this respect.
分析肺朗格汉斯细胞组织细胞增多症的形态学表现，以明确诊断特征。
对7例肺朗格汉斯细胞组织细胞增多症患者进行苏木精-伊红（H&E）染色及免疫组化研究。
7例患者均可见朗格汉斯细胞浸润。还可见炎性细胞浸润、间质纤维化及局灶性坏死。这些细胞表达S-100（7/7）、CD68（3/7）和CD1a（5/5）。
如果影像学检查怀疑为朗格汉斯细胞组织细胞增多症，强烈建议进行肺活检以明确诊断。S-100和CD1a免疫染色在这方面也有帮助。
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