人类疼痛性自我刺激期间的皮质脊髓兴奋性：一项经颅磁刺激研究。
Corticospinal excitability during painful self-stimulation in humans: a transcranial magnetic stimulation study.
作者信息
Fadiga Luciano, Craighero Laila, Dri Guanita, Facchin Patrizia, Destro Maddalena Fabbri, Porro Carlo A
机构信息
Department of Biomedical Sciences and Advanced Therapies, Section of Human Physiology, University of Ferrara, via Fossato di Mortara 17/19, 44100 Ferrara, Italy.
出版信息
Neurosci Lett. 2004 May 6;361(1-3):250-3. doi: 10.1016/j.neulet.2003.12.016.
We investigated changes in the corticospinal pattern of activity in healthy volunteers during sustained noxious and non-noxious mechanical stimulation of the first hand digit, resulting from active (self-stimulation) or passive (externally-induced) pressing against a sharp or blunted tip. The results indicate that, in order to press a finger onto a noxious stimulus with the same force generated to press onto a non-noxious one, the motor cortex adopts a peculiar strategy in terms of recruitment of motor units. This is reflected by an increase of corticospinal excitability (as revealed by motor potentials evoked by transcranial magnetic stimulation of the contralateral primary motor cortex) and EMG activity of agonist muscles, possibly related to an increase of motor unit synchronization.
我们研究了健康志愿者在对手的食指进行持续的有害和无害机械刺激过程中皮质脊髓活动模式的变化，这些刺激是通过主动（自我刺激）或被动（外部诱导）按压尖锐或钝的尖端产生的。结果表明，为了用与按压无害刺激相同的力量将手指按压在有害刺激上，运动皮层在运动单位的募集方面采用了一种特殊策略。这表现为皮质脊髓兴奋性增加（通过对侧初级运动皮层的经颅磁刺激诱发的运动电位揭示）以及主动肌的肌电图活动增加，这可能与运动单位同步性增加有关。
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