慢性髓性白血病中的e6a2 BCR-ABL转录本：它与侵袭性疾病有关吗？
e6a2 BCR-ABL transcript in chronic myeloid leukemia: is it associated with aggressive disease?
作者信息
Colla Simona, Sammarelli Gabriella, Voltolini Simone, Crugnola Monica, Sebastio Paola, Giuliani Nicola
出版信息
Haematologica. 2004 May;89(5):611-3.
PMID:15136228
Abstract
We describe the fourth case of e6a2 BCR-ABL transcript in a patient with chronic myeloid leukemia (CML), using reverse transcriptase polymerase chain reaction (RT-PCR) and sequencing analysis. The clinical and hematologic features and the aggressive course of disease in our patient and in the others reported in literature lead us to hypothesize that this atypical rearrangement may be associated with a worse prognosis.
摘要
我们通过逆转录聚合酶链反应（RT-PCR）和测序分析，描述了慢性髓性白血病（CML）患者中e6a2 BCR-ABL转录本的第四例病例。我们患者以及文献中报道的其他患者的临床和血液学特征及疾病的侵袭性病程，使我们推测这种非典型重排可能与更差的预后相关。
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