Pankratz N, Uniacke S K, Halter C A, Rudolph A, Shults C W, Conneally P M, Foroud T, Nichols W C
Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, IN, USA.
Neurology. 2004 May 11;62(9):1616-8. doi: 10.1212/01.wnl.0000123112.51368.10.
A genome screen to identify genes influencing the age at Parkinson disease (PD) onset was completed using 276 families without parkin mutations. Significant evidence of linkage to chromosome 2p near the PARK3 locus (logarithm of odds [lod] = 4.8) was observed. Evidence of linkage was also detected to chromosomes 1q (lod = 3.0) and 8q (lod = 2.6). These data suggest that the genes influencing age at PD onset likely differ from those that contribute to PD susceptibility.
利用276个无帕金基因突变的家族完成了一项基因组筛查，以确定影响帕金森病（PD）发病年龄的基因。观察到与PARK3基因座附近的2号染色体p臂存在显著连锁证据（优势对数[lod]=4.8）。还检测到与1号染色体q臂（lod=3.0）和8号染色体q臂（lod=2.6）存在连锁证据。这些数据表明，影响PD发病年龄的基因可能与导致PD易感性的基因不同。
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