Mohr W, Endres-Klein R
Abteilung Pathologie, Universität Ulm.
Pathologe. 2004 May;25(3):202-8. doi: 10.1007/s00292-003-0664-3.
Diagnostic pathological examination of surgical specimens from patients with hip joint osteoarthrosis occasionally exhibits as yet undescribed pseudocysts consisting of folded granular membranes in necrotic or chondroid tissues. When stained with Sudan red, the content of these cysts indicates the presence of lipid substances. The presence of S100 protein-positive cells with intracytoplasmic fat vacuoles as well as such cells in the walls indicate that they develop from fat inclusions occurring in the chondroid cells of the labrum. Two different wall structures were detected by electron microscopy. The first type exhibited small walls of a granular material similar to the endoplasmic reticulum that surrounds intracytoplasmic fat globules. The second type consisted of broad layers of very tiny granules indicating a more advanced stage of the development of these cysts. The reason for the occurrence of these "chondrocytogenic lipid cysts" remains unknown-it may be assumed that they are due to mechanical labrum destruction that occurs in osteoarthrosis.
髋关节骨关节炎患者手术标本的诊断性病理检查偶尔会发现一些尚未描述过的假囊肿,这些假囊肿由坏死或软骨样组织中的折叠颗粒膜构成。用苏丹红染色时,这些囊肿的内容物显示存在脂质物质。存在带有胞浆内脂肪空泡的S100蛋白阳性细胞以及囊肿壁中的此类细胞,表明它们源自盂唇软骨样细胞中出现的脂肪包涵体。通过电子显微镜检测到两种不同的壁结构。第一种类型表现为类似于内质网的颗粒状物质构成的薄壁,围绕着胞浆内脂肪球。第二种类型由非常微小颗粒的宽层组成,表明这些囊肿处于更高级的发育阶段。这些“软骨源性脂质囊肿”出现的原因尚不清楚——可以推测它们是由于骨关节炎中发生的盂唇机械性破坏所致。