通过血脑屏障清除淀粉样蛋白。
Clearing amyloid through the blood-brain barrier.
作者信息
Zlokovic Berislav V
机构信息
Frank P. Smith Laboratories for Neuroscience, Department of Neurological Surgery, University of Rochester Medical Center, New York 14642, USA.
出版信息
J Neurochem. 2004 May;89(4):807-11. doi: 10.1111/j.1471-4159.2004.02385.x.
According to the amyloid hypothesis, accumulation of amyloid beta-peptide (A beta) in the brain is the primary pathogenic event in Alzheimer's disease (AD). Recent evidence indicates that A beta within the intravascular space is linked to A beta deposited in the brain suggesting that transport of A beta between the brain, blood and cerebrospinal fluid, and across the blood-brain barrier, regulates brain A beta. Thus, understanding A beta exchanges between brain and blood, and vice versa, and developing transport-based systemic A beta-lowering strategies may provide new important insights into pathogenesis and therapeutic control of AD.
根据淀粉样蛋白假说，淀粉样β肽（Aβ）在大脑中的积累是阿尔茨海默病（AD）的主要致病事件。最近的证据表明，血管内空间中的Aβ与沉积在大脑中的Aβ有关，这表明Aβ在大脑、血液和脑脊液之间以及穿过血脑屏障的转运调节着大脑中的Aβ。因此，了解Aβ在大脑和血液之间的交换，反之亦然，并开发基于转运的全身性降低Aβ策略，可能为AD的发病机制和治疗控制提供新的重要见解。
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