NOD2基因多态性、克罗恩病与肺结核易感性

Polymorphism in NOD2, Crohn's disease, and susceptibility to pulmonary tuberculosis.

作者信息

Stockton Jemima C, Howson Joanna M M, Awomoyi Agnes A, McAdam Keith P, Blackwell Jenefer M, Newport Melanie J

机构信息

Department of Medicine, University of Cambridge School of Clinical Medicine, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

出版信息

FEMS Immunol Med Microbiol. 2004 Jun 1;41(2):157-60. doi: 10.1016/j.femsim.2004.02.004.

DOI:10.1016/j.femsim.2004.02.004

PMID:15145460

Abstract

The nucleotide oligomerization binding domain 2 gene (NOD2) encodes an intracellular receptor for bacterial components, which is expressed in monocytes and is associated with Crohn's Disease (CD). This finding, along with epidemiological evidence, supports a role for infection in the pathogenesis of CD. Speculation that mycobacteria are involved in CD led us to investigate NOD2 in susceptibility to tuberculosis (TB), a global public health problem caused by Mycobacterium tuberculosis. CD-associated NOD2 variants were absent in a case-control study of 640 Gambians, where CD is rare. Novel NOD2 promoter polymorphisms were identified but showed no association with TB in this African population sample.

摘要

核苷酸寡聚化结构域2基因（NOD2）编码一种细菌成分的细胞内受体，该受体在单核细胞中表达，并与克罗恩病（CD）相关。这一发现以及流行病学证据支持感染在CD发病机制中起作用。关于分枝杆菌参与CD的推测促使我们研究NOD2在结核病（TB）易感性中的作用，TB是由结核分枝杆菌引起的全球公共卫生问题。在一项对640名冈比亚人的病例对照研究中未发现与CD相关的NOD2变体，在该地区CD较为罕见。研究发现了新型NOD2启动子多态性，但在这个非洲人群样本中，这些多态性与TB没有关联。