对安慰剂有反应的帕金森病患者丘脑底核单个神经元的活动减少。
Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus.
作者信息
Benedetti Fabrizio, Colloca Luana, Torre Elena, Lanotte Michele, Melcarne Antonio, Pesare Marina, Bergamasco Bruno, Lopiano Leonardo
机构信息
Department of Neuroscience, Clinical and Applied Physiology Program, University of Turin Medical School, Corso Raffaello 30, 10125 Turin, Italy.
出版信息
Nat Neurosci. 2004 Jun;7(6):587-8. doi: 10.1038/nn1250. Epub 2004 May 16.
Placebo administration is known to affect the brain both in pain and in Parkinson disease. Here we show that placebo treatment caused reduced activity in single neurons in the subthalamic nucleus of placebo-responsive Parkinsonian patients. These changes in activity were tightly correlated with clinical improvement; no decrease in activity occurred when the clinical placebo response was absent.
已知安慰剂给药在疼痛和帕金森病中均会影响大脑。在此我们表明，安慰剂治疗使安慰剂反应性帕金森病患者丘脑底核中的单个神经元活动减少。这些活动变化与临床改善密切相关；当不存在临床安慰剂反应时，活动并未减少。
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