准备工作——这个芽是给高尔基体的。

Mise en place-this bud's for the Golgi.

作者信息

LaPointe Paul, Gurkan Cemal, Balch William E

机构信息

The Scripps Research Institute, Department of Cell, and The Institute for Childhood and Neglected Disease, 10550 N. Torrey Pines Road, La Jolla, CA 92130, USA.

出版信息

Mol Cell. 2004 May 21;14(4):413-4. doi: 10.1016/s1097-2765(04)00267-9.

DOI:10.1016/s1097-2765(04)00267-9

PMID:15149587

Abstract

Selective cargo export from the endoplasmic reticulum is brought about by the budding of COPII vesicles. While the main structural components of the COPII coat have been identified and characterized, the regulatory event(s) promoting COPII vesicle biogenesis and cargo selection still remains largely unknown. New data by Glick and colleagues suggest that Sec12 and COPII function may be downstream of important early events coordinated by transitional ER (tER) exit sites.

摘要

从内质网进行选择性货物输出是由COPII囊泡出芽实现的。虽然COPII衣被的主要结构成分已被鉴定和表征，但促进COPII囊泡生物发生和货物选择的调控事件在很大程度上仍不清楚。Glick及其同事的新数据表明，Sec12和COPII功能可能处于由内质网过渡（tER）出口位点协调的重要早期事件的下游。