[Ⅰ型复杂性区域疼痛综合征的药物治疗]

[Drug therapy in complex regional pain syndrome type I].

作者信息

Von Eisenhart-Rothe R, Rittmeister M

机构信息

Orthopädische Universitätsklinik Stiftung Friedrichsheim, Frankfurt.

出版信息

Orthopade. 2004 Jul;33(7):796-803. doi: 10.1007/s00132-004-0674-8.

DOI:10.1007/s00132-004-0674-8

PMID:15150686

Abstract

Pharmacologic treatment options for complex regional pain syndrome (CRPS) type I are discussed and drug effectiveness is graded according to the level of evidence available. Various drug strategies in the treatment of CRPS type I, i.e. NSAIDs, corticosteroids, free radical scavengers, antidepressants, anticonvulsants, local anesthetics, opioid analgesics, clonidine, capsaicin, NMDA receptor antagonists, calcitonin, bisphosphonates, GABA(B)-agonists, alpha-blockers, IVRA (bretylium/ketanserin), IVRA (clonidine), IVRSB, local anesthetics sympathetic blockade, GLOA and iloprost are discussed.

摘要

讨论了Ⅰ型复杂性区域疼痛综合征（CRPS）的药物治疗选择，并根据现有证据水平对药物疗效进行分级。文中讨论了Ⅰ型CRPS治疗中的各种药物策略，即非甾体抗炎药、皮质类固醇、自由基清除剂、抗抑郁药、抗惊厥药、局部麻醉药、阿片类镇痛药、可乐定、辣椒素、N-甲基-D-天冬氨酸（NMDA）受体拮抗剂、降钙素、双膦酸盐、γ-氨基丁酸B（GABA(B)）激动剂、α受体阻滞剂、静脉区域镇痛（溴苄铵/酮色林）、静脉区域镇痛（可乐定）、静脉区域交感神经阻滞、胍乙啶局部阻滞和伊洛前列素。