4-氟代尿苷二磷酸-N-乙酰胞壁酸五肽的合成作为细菌生长抑制剂

Synthesis of 4-fluorinated UDP-MurNAc pentapeptide as an inhibitor of bacterial growth.

作者信息

Ueda Taichi, Feng Fei, Sadamoto Reiko, Niikura Kenichi, Monde Kenji, Nishimura Shin-Ichiro

机构信息

Bio-Macromolecular Chemistry Lab, Division of Biological Sciences, Graduate School of Science, Frontier Research Center for Post-Genomic Science and Technology, Hokkaido University, Kita 21, Nishi 11, Sapporo 001-0021 Japan.

出版信息

Org Lett. 2004 May 27;6(11):1753-6. doi: 10.1021/ol049598w.

DOI:10.1021/ol049598w

PMID:15151406

Abstract

4-Fluorinated UDP-MurNAc pentapeptide, 2, has been synthesized. In our previous study, UDP-MurNAc pentapeptide analogue 1 was found to be incorporated into the bacterial cell wall through biosynthesis. Compound 2 showed growth-inhibition activity against Gram-positive bacteria when it was added to growth media at 0.01 mg/mL. [structure--see text]

摘要

4-氟代尿苷二磷酸-N-乙酰胞壁酸五肽（2）已被合成。在我们之前的研究中，发现尿苷二磷酸-N-乙酰胞壁酸五肽类似物1通过生物合成被整合到细菌细胞壁中。当化合物2以0.01 mg/mL的浓度添加到生长培养基中时，对革兰氏阳性菌表现出生长抑制活性。[结构——见正文]