儿童IgA肾病：临床特点与治疗方法

Pediatric IgA nephropathies: clinical aspects and therapeutic approaches.

作者信息

Delos Santos Noel M, Wyatt Robert J

机构信息

Children's Foundation Research Center at the Le Bonheur Children's Medical Center and the Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, TN, USA.

出版信息

Semin Nephrol. 2004 May;24(3):269-86. doi: 10.1016/j.semnephrol.2004.01.007.

DOI:10.1016/j.semnephrol.2004.01.007

PMID:15156531

Abstract

The pediatric IgA nephropathies are IgA nephrothapy (Berger's Disease) and Henoch-Schönlein purpura nephritis. Both conditions are reviewed in detail with respect to epidemiology, clinical features, outcome, prognostic markers, and therapeutic approaches. For both conditions variable disease severity and outcome along with the lack of conclusive evidence for efficacy of treatment based on randomized clinical trials makes it difficult to make strong recommendations regarding therapy.

摘要

儿童IgA肾病包括IgA肾炎（伯杰氏病）和过敏性紫癜性肾炎。本文将从流行病学、临床特征、预后、预后标志物和治疗方法等方面对这两种疾病进行详细综述。由于这两种疾病的严重程度和预后各不相同，且缺乏基于随机临床试验的治疗有效性的确凿证据，因此很难就治疗提出强有力的建议。