p75神经营养因子受体具有积极的混杂性：新的伙伴和新的见解。

p75NTR is positively promiscuous: novel partners and new insights.

作者信息

Barker Philip A

机构信息

Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Quebec, Canada.

出版信息

Neuron. 2004 May 27;42(4):529-33. doi: 10.1016/j.neuron.2004.04.001.

DOI:10.1016/j.neuron.2004.04.001

PMID:15157416

Abstract

Although identified almost 20 years ago, the precise physiological role of the p75 neurotrophin receptor (p75NTR) has remained elusive. Recent studies have revealed that p75NTR is a component of three distinct receptor platforms that bind different ligands and that, under differing circumstances, facilitate cell survival, cell death, or growth inhibition. These recent developments provide new insights into the functions of this enigmatic receptor.

摘要

尽管p75神经营养因子受体（p75NTR）在近20年前就已被发现，但其确切的生理作用仍不清楚。最近的研究表明，p75NTR是三个不同受体平台的组成部分，这些平台结合不同的配体，并且在不同情况下促进细胞存活、细胞死亡或生长抑制。这些最新进展为这个神秘受体的功能提供了新的见解。