基质金属蛋白酶（MMP）-2和MMP-9在癌症（如急性白血病）中的可能作用。
The possible role of matrix metalloproteinase (MMP)-2 and MMP-9 in cancer, e.g. acute leukemia.
作者信息
Klein G, Vellenga E, Fraaije M W, Kamps W A, de Bont E S J M
机构信息
Division of Pediatric Oncology and Hematology, Beatrix Children's Hospital, Groningen University Hospital, Hanzeplein 1, P.O. Box 30.001, Groningen 9700 RB, The Netherlands.
出版信息
Crit Rev Oncol Hematol. 2004 May;50(2):87-100. doi: 10.1016/j.critrevonc.2003.09.001.
In the past decades, a lot of effort has been put in identifying the role of matrix metalloproteinases (MMPs) in cancer. The main role of MMPs in angiogenesis, tumor growth and metastasis is degradation of extracellular matrix (ECM) and release and/or activation of growth factors through their degradative activity. The degradative activity finally results in cancer progression. MMP-inhibitors (MMPIs) have already been designed and tested, based on the degradative role of MMPs in cancer progression. First clinical trials with MMPIs have been performed with disappointing results, showing that in order to use MMP-inhibition the mechanisms underlying MMP-expression in cancer have to be further elucidated. This paper reviews the mechanisms of MMPs on molecular and cellular level and discusses the role for MMPs and MMP-inhibition in cancer with special focus on acute leukemia.
在过去几十年里，人们付出了诸多努力来确定基质金属蛋白酶（MMPs）在癌症中的作用。MMPs在血管生成、肿瘤生长和转移中的主要作用是通过其降解活性降解细胞外基质（ECM）以及释放和/或激活生长因子。这种降解活性最终导致癌症进展。基于MMPs在癌症进展中的降解作用，人们已经设计并测试了MMP抑制剂（MMPIs）。MMPIs的首次临床试验结果令人失望，这表明为了利用MMP抑制作用，必须进一步阐明癌症中MMP表达的潜在机制。本文综述了MMPs在分子和细胞水平上的机制，并讨论了MMPs和MMP抑制在癌症中的作用，特别关注急性白血病。
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