氩饱和水溶液中抗肿瘤醌类的声化学：增强的高铁细胞色素c还原作用

Sonochemistry of antitumor quinones in argon-saturated aqueous solutions: enhanced ferricytochrome c reduction.

作者信息

Lopez-Colón Dalia, Alegría Antonio E

机构信息

Department of Chemistry, University of Puerto Rico at Humacao, CUH Station, Humacao 00791, Puerto Rico.

出版信息

Ultrason Sonochem. 2004 Jul;11(5):311-6. doi: 10.1016/j.ultsonch.2003.07.001.

DOI:10.1016/j.ultsonch.2003.07.001

PMID:15157861

Abstract

Sonolysis of argon-saturated aqueous antitumor quinone solutions resulted in an enhancement in ferricytochrome c (Cyt c) reduction. Partial inhibition of these reduction enhancements by addition of superoxide dismutase evidences the production of superoxide ions. No correlation between quinone hydrophobicity or redox potential is observed in the extent of Cyt c reduction. The semiquinone of the parent quinone as well as other quinone-derived reductants are proposed as the electron shuttle intermediates which reduce Cyt c.

摘要

对氩气饱和的抗肿瘤醌类水溶液进行超声处理，可增强高铁细胞色素c（Cyt c）的还原作用。添加超氧化物歧化酶可部分抑制这些还原增强作用，这证明了超氧离子的产生。在Cyt c还原程度方面，未观察到醌类疏水性或氧化还原电位之间的相关性。母体醌的半醌以及其他醌衍生的还原剂被认为是还原Cyt c的电子穿梭中间体。