肾祖细胞移植后的肾脏器官发生

Organogenesis of kidneys following transplantation of renal progenitor cells.

作者信息

Hammerman Marc R

机构信息

Departments of Medicine, and Cell Biology and Physiology, Renal Division, Box 8126, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, MO 63110, USA.

出版信息

Transpl Immunol. 2004 Apr;12(3-4):229-39. doi: 10.1016/j.trim.2003.12.002.

DOI:10.1016/j.trim.2003.12.002

PMID:15157917

Abstract

One novel solution to the shortage of human organs available for transplantation envisions 'growing' new organs in situ via xenotransplantation of developing anlagen from animal embryos. We and others have shown that renal progenitor cells (metanephroi) transplanted into animal hosts undergo organogenesis (differentiation and growth), become vascularized by blood vessels of host origin and exhibit excretory function. Metanephroi can be stored for up to 3 days in vitro prior to transplantation with no impairment in growth or function post-implantation. Metanephroi can be transplanted across both concordant (rat to mouse) and highly disparate (pig to rodent) xenogeneic barriers. Here we review studies exploring the potential therapeutic use of embryonic kidney transplantation as a means to achieve renal organogenesis.

摘要

一种解决人体可用于移植的器官短缺问题的新方法设想通过移植动物胚胎发育中的原基进行异种移植，在原位“培育”新器官。我们和其他人已经表明，移植到动物宿主中的肾祖细胞（后肾）会经历器官发生（分化和生长），由宿主来源的血管形成血管，并表现出排泄功能。后肾在移植前可在体外保存长达3天，植入后生长或功能不受损害。后肾可以跨越一致的（大鼠到小鼠）和高度不同的（猪到啮齿动物）异种屏障进行移植。在这里，我们回顾了探索胚胎肾移植作为实现肾器官发生手段的潜在治疗用途的研究。