[Primary testicular lymphomas. Clinicopathologic analysis of 10 cases. Experience at the National Institute of Cancerology in Mexico City].

UNLABELLED

Non-Hodgkin lymphoma is the most common primary testicular neoplasm of older men but is rare in young men. The vast majority of primary testicular lymphomas (PTL) are intermediate- to high-grade lymphomas.

OBJECTIVE

To describe the clinical, morphologic, and immunophenolypic characteristics of PTL seen in a referral center.

MATERIAL AND METHODS

We reviewed the cases of PTL seen from 1986 to 1999. We obtained data of laboratory, tests, clinical course, treatment, and immunohistochemical studies.

RESULTS

10 patients with diagnosis of PTL were identified. Median age was 62.3 years (range 42-81 years), and nine patients underwent orchiectomy as initial therapeutic procedure. Other treatment modalities after diagnosis included combination chemotherapy (60%) and combination radiotherapy (20%). Histologically, testes showed diffuse dense infiltration of large lymphoma cells. All cases were classified as diffuse large cell lymphoma according to REAL classification. Eight cases were studied with use of paraffin-section immunoperoxidase, 7/8 tumors were B-lineage lymphomas, and one was a T-lineage lymphoma.