Immunosuppressants.

The role and pharmacology of a variety of immunosuppressant agents in the gastrointestinal tract and liver are reviewed in this article. Immunosuppressants covered include cyclosporine, corticosteroids, OKT3, antithymocyte globulin, azathioprine, methotrexate, and FK506. Guidelines for the use and complications of immunosuppressants in liver, pancreas, and small bowel transplantations are presented. Controlled and uncontrolled data for use of immunosuppressants in the management of gastrointestinal and hepatic disorders are also described.