R353Q多态性、活化凝血因子VII与日本男性早发心肌梗死风险

R353Q polymorphism, activated factor VII, and risk of premature myocardial infarction in Japanese men.

作者信息

Ogawa Masakazu, Abe Satoshi, Biro Sadatoshi, Saigo Masahiko, Kihara Takashi, Setoyama Shiro, Matsuoka Tatsuru, Toda Hitoshi, Torii Hiroyuki, Atsuchi Yoshihiko, Toyama Yoshifumi, Tateishi Shigeki, Minagoe Shinichi, Maruyama Ikuro, Tei Chuwa

机构信息

Department of Cardiovascular, Graduate School of Medicine, Kagoshima University, Japan.

出版信息

Circ J. 2004 Jun;68(6):520-5. doi: 10.1253/circj.68.520.

DOI:10.1253/circj.68.520

PMID:15170085

Abstract

BACKGROUND

The association between myocardial infarction (MI) and the R353Q polymorphism of the Factor VII (FVII) gene, which reportedly influences FVII concentrations, activated Factor VII (FVIIa), or FVII antigen (FVIIag), remains controversial.

METHODS AND RESULTS

The present case - control study in 127 Japanese men with their first MI at or before 45 years of age and 150 matched healthy controls was designed to clarify this association in premature MI. R353Q polymorphism was determined by polymerase chain reaction, and plasma concentrations of FVIIa and FVIIag were assayed. The distribution of the RR, RQ, and QQ genotypes with respect to R353Q polymorphism was 117, 10, and 0 in the patients, and 131, 17, and 2 in the controls. The Q allele was negatively associated with premature MI (odds ratio =0.41, p=0.038). The plasma concentration of FVIIa was slightly higher in patients (55.1+/-40.9 U/L) than in controls (44.8+/-20.2 U/L), but not significantly (p=0.078); the plasma concentration of FVIIag did not differ between patients (88.7+/-15.7%) and controls (87.0+/-9.0%) (p=0.557). Plasma FVIIa concentrations were influenced by R353Q polymorphism (p<0.001).

CONCLUSIONS

The Q allele may be protective against premature MI.

摘要

背景

据报道，因子VII（FVII）基因的R353Q多态性会影响FVII浓度、活化因子VII（FVIIa）或FVII抗原（FVIIag），但其与心肌梗死（MI）之间的关联仍存在争议。

方法与结果

本病例对照研究纳入了127名45岁及以下首次发生MI的日本男性以及150名匹配的健康对照，旨在阐明早发性MI中的这种关联。通过聚合酶链反应确定R353Q多态性，并检测FVIIa和FVIIag的血浆浓度。患者中RR、RQ和QQ基因型在R353Q多态性方面的分布分别为117、10和0，对照组分别为131、17和2。Q等位基因与早发性MI呈负相关（优势比=0.41，p=0.038）。患者的FVIIa血浆浓度（55.1±40.9 U/L）略高于对照组（44.8±20.2 U/L），但差异无统计学意义（p=0.078）；患者（88.7±15.7%）和对照组（87.0±9.0%）的FVIIag血浆浓度无差异（p=0.557）。血浆FVIIa浓度受R353Q多态性影响（p<0.001）。