Polak Wojciech G, Gładysz Andrzej
Department of Vascular, General and Transplant Surgery, Medical University in Wroclaw, Poland.
Ann Transplant. 2003;8(4):16-21.
HIV infection has been traditionally considered to be an absolute contraindication for solid organ transplantation. Recent advances in HIV treatment, as highly active antiretroviral therapy (HAART), significantly reduced HIV-related mortality and morbidity. At the same time the number of HIV-infected patients with end-stage organ diseases constantly increased. Current data describing solid organ transplantation in HIV-infected patients demonstrated comparable outcome to that in the HIV-negative population. In light of this, solid organ transplantation should be considered as a treatment option for selected HIV-positive patients with end-stage organ disease.
传统上,HIV感染一直被视为实体器官移植的绝对禁忌证。随着高效抗逆转录病毒疗法(HAART)等HIV治疗方法的最新进展,HIV相关的死亡率和发病率显著降低。与此同时,患有终末期器官疾病的HIV感染患者数量不断增加。目前关于HIV感染患者实体器官移植的数据表明,其结果与HIV阴性人群相当。鉴于此,对于选定的患有终末期器官疾病的HIV阳性患者,应考虑将实体器官移植作为一种治疗选择。