Genovese Mark C, Kremer Joel M
Division of Immunology and Rheumatology, Stanford University Medical Center, 1000 Welch Road, Suite 203, Palo Alto, CA 94304, USA.
Rheum Dis Clin North Am. 2004 May;30(2):311-28, vi-vii. doi: 10.1016/j.rdc.2004.01.004.
Etanercept is effective in the treatment of rheumatoid arthritis (RA)when used as monotherapy and in combination with methotrexate(MTX). Radiographic progression of disease was slowed significantly when the drug was used for a 24-month period and was statistically significantly better than MTX. In addition to its use in RA,etanercept is approved by the U.S. Food and Drug Administration for other rheumatologic conditions, including psoriatic arthritis,ankylosing spondylitis, and juvenile chronic arthritis.
依那西普作为单一疗法或与甲氨蝶呤（MTX）联合使用时，对类风湿性关节炎（RA）的治疗有效。当使用该药物24个月时，疾病的影像学进展显著减缓，且在统计学上显著优于甲氨蝶呤。除了用于治疗类风湿性关节炎外，依那西普还被美国食品药品监督管理局批准用于其他风湿性疾病，包括银屑病关节炎、强直性脊柱炎和青少年慢性关节炎。
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