Overexpression of LIM kinase 1 renders resistance to apoptosis in PC12 cells by inhibition of caspase activation. - Suppr | 超能文献

Overexpression of LIM kinase 1 renders resistance to apoptosis in PC12 cells by inhibition of caspase activation.

作者信息

Yang E, Kim H, Lee J, Shin J S, Yoon H, Kim S J, Choi I H

机构信息

Department of Microbiology, Brain Korea 21 Project for Medical Science, and Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul, South Korea.

出版信息

Cell Mol Neurobiol. 2004 Apr;24(2):181-92. doi: 10.1023/b:cemn.0000018615.84358.33.

DOI:10.1023/b:cemn.0000018615.84358.33

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11529917/

Abstract

LIM kinases (LIMKs) regulate actin polymerization by phosphorylating cofilin and are predominantly expressed in neural tissue. In this study, the effect of LIMK1 overexpression in PC12 cell apoptosis was investigated. PC12 cells overexpressing the wild-type LIMK1 were more resistant to serum-withdrawal-induced cell death and the level of caspase 3 activation in these cells was lower than in the control PC12 cells or than in the PC12 cells expressing a mutant LIMK1 lacking the kinase domain. The inhibition of JNK activation was observed in the PC12 cells overexpressing the wild-type LIMK1 after serum withdrawal. These results suggest that the LIMK1 might allow resistance to apoptosis in PC12 cells by inhibiting JNK activation.

摘要

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