α,β-不饱和肟在分子内[4 + 2]环加成反应中的有趣行为。
Interesting behavior of alpha,beta-unsaturated oximes in intramolecular [4 + 2] cycloaddition reactions.
作者信息
François David, Maden Amy, Murray William V
机构信息
Johnson & Johnson Pharmaceutical Research and Development, LLC, 1000 Route 202, Box 300, Raritan, New Jersey 08869, USA.
出版信息
Org Lett. 2004 Jun 10;6(12):1931-4. doi: 10.1021/ol049640n.
PMID:15176786
Abstract
[structure: see text] Intramolecular [4 + 2] cycloaddition using alpha,beta-unsaturated oximes was explored. The reactions proceeded under unusually facile conditions to furnish the nitrones. The latter were subsequently reacted with DMAD to afford [3 + 2] cycloaddition products.
摘要
[结构：见正文] 对使用α,β-不饱和肟的分子内[4 + 2]环加成反应进行了探索。反应在异常温和的条件下进行，生成硝酮。后者随后与富马酸二甲酯反应，得到[3 + 2]环加成产物。
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