三叶肽在肠化生亚型中的表达。

Expression of trefoil peptides in the subtypes of intestinal metaplasia.

作者信息

Kim Byung-Wook, Kim Kyoung-Mee, Lee Bo-In, Maeng Lee-So, Choi Hwang, Cho Se-Hyun, Chae Hiun-Suk, Kim Jae-Kwang, Choi Kyu-Yong, Chung In-Sik

机构信息

Department of Internal Medicine, The Catholic University of Korea, Seoul, South Korea.

出版信息

Peptides. 2004 May;25(5):779-83. doi: 10.1016/j.peptides.2003.12.021.

DOI:10.1016/j.peptides.2003.12.021

PMID:15177872

Abstract

We studied the expression of trefoil peptides in the different types of intestinal metaplasia of the stomach. Endoscopic biopsy was performed in 132 patients with dyspepsia. Intestinal metaplasia subtype was classified according to the pattern of alcian blue/PAS staining and high iron diamine staining. Expression of trefoil peptides was measured by immunohistochemistry. TFF1 and TFF3 were mainly expressed in goblet cells and TFF2 in columnar cells in all the types of intestinal metaplasia. There was a gradual decrease of TFF1 and TFF3, and increase of TFF2, during the progression of intestinal metaplasia from type I to type III via the type II intermediate.

摘要

我们研究了三叶肽在胃不同类型肠化生中的表达情况。对132例消化不良患者进行了内镜活检。根据阿尔辛蓝/过碘酸雪夫染色和高铁二胺染色模式对肠化生亚型进行分类。通过免疫组织化学检测三叶肽的表达。在所有类型的肠化生中，TFF1和TFF3主要表达于杯状细胞，TFF2表达于柱状细胞。在肠化生从I型经II型中间体进展至III型的过程中，TFF1和TFF3逐渐减少，TFF2逐渐增加。