Noppeney U, Phillips J, Price C
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK.
Neuropsychologia. 2004;42(9):1269-80. doi: 10.1016/j.neuropsychologia.2003.12.014.
Semantic retrieval consistently activates left inferior frontal regions, yet lesions to these areas do not typically result in semantic deficits. This discrepancy has led to the hypothesis that left prefrontal areas are primarily involved in executive processes while semantic information is retrieved from temporal cortices. We investigated semantic executive processing by changing, over trials, the semantic association to a stimulus. Using fMRI and PET, we demonstrate that changes in semantic association increased activation in temporal as well as frontal areas. The similar effects in temporal and frontal areas suggest that semantic executive processes are not confined to the left inferior frontal cortex but might be distributed throughout the semantic system.
语义检索始终会激活左前额叶下部区域，但这些区域受损通常不会导致语义缺陷。这种差异导致了一种假说，即左前额叶区域主要参与执行过程，而语义信息是从颞叶皮质检索的。我们通过在多次试验中改变对刺激的语义关联来研究语义执行过程。使用功能磁共振成像（fMRI）和正电子发射断层扫描（PET），我们证明语义关联的变化增加了颞叶和额叶区域的激活。颞叶和额叶区域的类似效应表明，语义执行过程并不局限于左前额叶下部皮质，而是可能分布在整个语义系统中。
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