Petermann Thomas, De Los Rios Paolo
Institut de Physique Théorique, Université de Lausanne, CH-1015, Lausanne, Switzerland.
J Theor Biol. 2004 Jul 7;229(1):1-11. doi: 10.1016/j.jtbi.2004.02.017.
The spread of a virus is an example of a dynamic process occurring on a discrete spatial arrangement. While the mean-field approximation reasonably reproduces the spreading behaviour for topologies where the number of connections per node is either high or strongly fluctuating and for those that show small-world features, it is inaccurate for lattice structured populations. Various improvements upon the ordinary pair approximation based on a number of assumptions concerning the higher-order correlations have been proposed. To find approaches that allow for a derivation of their dynamics remains a great challenge. By representing the population with its connectivity patterns as a homogeneous network, we propose a systematic methodology for the description of the epidemic dynamics that takes into account spatial correlations up to a desired range. The equations that the dynamical correlations are subject to are derived in a straightforward way, and they are solved very efficiently due to their binary character. The method embeds very naturally spatial patterns such as the presence of loops characterizing the square lattice or the tree-like structure ubiquitous in random networks, providing an improved description of the steady state as well as the invasion dynamics.
病毒传播是在离散空间布局上发生的动态过程的一个例子。虽然平均场近似能够合理地再现连接数要么很多要么波动很大的拓扑结构以及具有小世界特征的拓扑结构的传播行为,但对于晶格结构的群体来说,它是不准确的。基于一些关于高阶相关性的假设,已经提出了对普通对近似的各种改进。要找到能够推导其动力学的方法仍然是一个巨大的挑战。通过将群体及其连接模式表示为均匀网络,我们提出了一种系统的方法来描述流行病动力学,该方法考虑了高达所需范围的空间相关性。动态相关性所遵循的方程是以直接的方式推导出来的,并且由于它们的二元性质,能够非常有效地求解。该方法非常自然地嵌入了空间模式,例如表征方格的环的存在或随机网络中普遍存在的树状结构,从而对稳态以及入侵动力学提供了改进的描述。