意义未明的IgA单克隆丙种球蛋白病伴周围神经病

IgA monoclonal gammopathy of undetermined significance with peripheral neuropathy.

作者信息

Mehndiratta M M, Sen K, Tatke M, Bajaj B K

机构信息

Department of Neurology, G.B. Pant Hospital, New Delhi 110002, India.

出版信息

J Neurol Sci. 2004 Jun 15;221(1-2):99-104. doi: 10.1016/j.jns.2004.02.020.

DOI:10.1016/j.jns.2004.02.020

PMID:15178222

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) and peripheral neuropathy may be causally linked. In most cases, the M-protein is of IgG or IgM type. Peripheral neuropathy associated with IgA MGUS is uncommon, and there are limited reports. Here, we report a case of a 55-year-old male who was diagnosed to have symmetrical sensorimotor peripheral neuropathy associated with IgA MGUS with deposits of IgA-monoclonal protein in the myelin sheath.

摘要

意义未明的单克隆丙种球蛋白病（MGUS）与周围神经病变可能存在因果关联。在大多数情况下，M蛋白为IgG或IgM型。与IgA MGUS相关的周围神经病变并不常见，相关报道有限。在此，我们报告一例55岁男性患者，其被诊断为与IgA MGUS相关的对称性感觉运动性周围神经病变，髓鞘中有IgA单克隆蛋白沉积。