纳曲酮用于俄罗斯圣彼得堡的海洛因依赖治疗。

Naltrexone for heroin dependence treatment in St. Petersburg, Russia.

作者信息

Krupitsky Evgeny M, Zvartau Edwin E, Masalov Dimitry V, Tsoi Marina V, Burakov Andrey M, Egorova Valentina Y, Didenko Tatyana Y, Romanova Tatyana N, Ivanova Eva B, Bespalov Anton Y, Verbitskaya Elena V, Neznanov Nikolai G, Grinenko Alexandr Y, O'Brien Charles P, Woody George E

机构信息

St. Petersburg Scientific Research Center of Addictions and Psychopharmacology, affiliated with St. Petersburg State Pavlov Medical University, Russia.

出版信息

J Subst Abuse Treat. 2004 Jun;26(4):285-94. doi: 10.1016/j.jsat.2004.02.002.

DOI:10.1016/j.jsat.2004.02.002

PMID:15182893

Abstract

Naltrexone may be more effective for treating opioid (heroin) dependence in Russia than in the U.S. because patients are mostly young and living with their parents, who can control medication compliance. In this pilot study we randomized 52 consenting patients who completed detoxification in St. Petersburg to a double blind, 6-month course of biweekly drug counseling and naltrexone, or counseling and placebo naltrexone. Significant differences in retention and relapse favoring naltrexone were seen beginning at 1 month and continuing throughout the study. At the end of 6 months, 12 of the 27 naltrexone patients (44.4%) remained in treatment and had not relapsed as compared to 4 of 25 placebo patients (16%; p<0.05). Since heroin dependence is the main way HIV is being spread in Russia, naltrexone is likely to improve treatment outcome and help reduce the spread of HIV if it can be made more widely available.

摘要

在俄罗斯，纳曲酮治疗阿片类药物（海洛因）依赖可能比在美国更有效，因为患者大多年轻且与父母同住，父母能够监督其服药依从性。在这项试点研究中，我们将圣彼得堡52名完成戒毒的自愿患者随机分为两组，一组接受为期6个月的双盲治疗，每两周进行一次药物咨询并服用纳曲酮，另一组接受咨询并服用纳曲酮安慰剂。从第1个月开始直至整个研究过程中，在留存率和复发率方面，纳曲酮组均显示出显著差异。6个月结束时，27名服用纳曲酮的患者中有12名（44.4%）仍在接受治疗且未复发，而25名服用安慰剂的患者中仅有4名（16%）；（p<0.05）。鉴于海洛因依赖是俄罗斯艾滋病传播的主要途径，如果纳曲酮能够更广泛地提供，那么它很可能改善治疗效果并有助于减少艾滋病的传播。