Karoui Sami, Boubaker Jalel, Filali Azza
Service de Gastro-entérologie A, Hôpital la Rabta, Tunis.
Tunis Med. 2004 Feb;82(2):185-9.
The aims of this review are to precise the incidence of non-Hodgkin's lymphoma and Hodgkin's disease in inflammatory bowel disease and to assess the relationship between immunosuppressive therapy and lymphoma in inflammatory bowel disease. Population-based data show that incidence of lymphoma is not increased in patients with Crohn's disease or ulcerative colitis. There is an increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low in all cohort studies. Relationship between immunosuppression and lymphoma in inflammatory bowel disease is confirmed by frequency of cerebral lymphoma and association with Epstein-Barr virus.
本综述的目的是明确炎症性肠病中非霍奇金淋巴瘤和霍奇金病的发病率,并评估免疫抑制治疗与炎症性肠病中淋巴瘤的关系。基于人群的数据表明,克罗恩病或溃疡性结肠炎患者的淋巴瘤发病率并未增加。接受免疫抑制治疗的炎症性肠病患者中非霍奇金淋巴瘤的发病率有所增加,但在所有队列研究中总体风险较低。脑淋巴瘤的发生率以及与爱泼斯坦-巴尔病毒的关联证实了炎症性肠病中免疫抑制与淋巴瘤之间的关系。