Feng Jian-ying, Zhang Kai, Gu Zhi-yuan, Shibata Takanori
Dept. of Orthodontics, Hospital of Stomatology, College of Medicine, Zhejiang University, Hangzhou 310006, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2004 Apr;22(2):100-2, 119.
To study the gene expression changes in extracellular matrix of condylar cartilage following disc anterior displacement of rabbit TMJ.
The right sides of 28 joints in 40 rabbits were subjected to surgical operation of disc displacement. The condylar Collagen II and Aggrecan mRNA expression were detected by in situ hybridization.
Collagen II and Aggrecan mRNA mainly expressed in the lower zone of condylar chondrocyte. Aggrecan mRNA decreased faster than collagen II following disc displacement, and adjusted to normal later.
Anterior disc displacement leads to alteration of extracellurar matrix gene expression in the condylar chondrocyte, which means the start of remodeling.
研究兔颞下颌关节盘前移位后髁突软骨细胞外基质的基因表达变化。
对40只兔28个关节的右侧进行盘移位手术。采用原位杂交法检测髁突Ⅱ型胶原和聚集蛋白聚糖mRNA的表达。
Ⅱ型胶原和聚集蛋白聚糖mRNA主要表达于髁突软骨细胞的深层。盘移位后聚集蛋白聚糖mRNA的下降速度快于Ⅱ型胶原,随后又恢复至正常水平。
盘前移位导致髁突软骨细胞外基质基因表达改变,提示关节改建开始。