接触伯克霍尔德菌会在健康个体中诱导细胞介导的免疫。
Exposure to Burkholderia pseudomallei induces cell-mediated immunity in healthy individuals.
作者信息
Govan B, Ketheesan N
机构信息
School of Medicine, James Cook University, Townsville, Australia.
出版信息
Clin Microbiol Infect. 2004 Jun;10(6):585-7. doi: 10.1111/j.1469-0691.2004.00918.x.
Melioidosis is an emerging tropical infection caused by the intracellular bacterium Burkholderia pseudomallei, and is associated with high mortality rates. Previous studies investigating the prevalence of melioidosis have based conclusions on serological evidence. However, cell-mediated immunity is more relevant for protection against an intracellular pathogen such as B. pseudomallei. This is the first demonstration that exposure to B. pseudomallei may lead to the formation of specific antibodies and the development of cell-mediated immunity in a healthy individual.
类鼻疽是一种由细胞内细菌类鼻疽伯克霍尔德菌引起的新发热带感染病，且与高死亡率相关。以往关于类鼻疽患病率的研究结论均基于血清学证据。然而，细胞介导的免疫对于抵御诸如类鼻疽伯克霍尔德菌这样的细胞内病原体更为关键。这是首次证明，在健康个体中，接触类鼻疽伯克霍尔德菌可能会导致特异性抗体的形成以及细胞介导免疫的发展。
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