Winzenburg Gesine, Schmidt Carsten, Fuchs Stefan, Kissel Thomas
Department of Pharmaceutics and Biopharmacy, Philipps-University of Marburg, Ketzerbach 63, Marburg, Lahn, Germany.
Adv Drug Deliv Rev. 2004 Jun 23;56(10):1453-66. doi: 10.1016/j.addr.2004.02.008.
Biodegradable polymers have been extensively studied for numerous drug delivery systems for human health purposes. The ever-increasing value of animals to human society allows the application of pharmaceutical developments in the veterinary field from those developed in human medicine. Although many similarities between the human and animal health industries exist there are also notable differences. This paper provides an insight into the animal health market with regard to the challenges and special considerations associated with veterinary drug delivery. It also gives an overview of biodegradable polymers that are used or have been tested in the veterinary field. The purpose of this paper is to highlight some recent developments in this area and to investigate the directions in which veterinary pharmaceutics is heading. In particular, examples of existing biodegradable veterinary drug delivery systems are presented together with applications including intravaginal devices, injectables and implantable systems.
出于人类健康目的，可生物降解聚合物已在众多药物递送系统中得到广泛研究。动物对人类社会的价值日益增加，使得人类医学中开发的药物可应用于兽医领域。尽管人类和动物健康产业存在许多相似之处，但也存在显著差异。本文深入探讨了动物健康市场，涉及与兽药递送相关的挑战和特殊考量。它还概述了已在兽医领域使用或经过测试的可生物降解聚合物。本文旨在突出该领域的一些最新进展，并探讨兽药制剂的发展方向。特别是，介绍了现有的可生物降解兽药递送系统的实例以及包括阴道内装置、注射剂和植入系统在内的应用。
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