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疑似宫颈妊娠的鉴别诊断及腹腔镜辅助子宫动脉结扎与宫腔镜下宫颈切除术联合的保守治疗

Differential diagnosis of suspected cervical pregnancy and conservative treatment with the combination of laparoscopy-assisted uterine artery ligation and hysteroscopic endocervical resection.

作者信息

Kung Fu-Tsai, Lin Hao, Hsu Te-Yao, Chang Chih-Yang, Huang Hsuan-Wei, Huang Li-Ying, Chou Yin-Jou, Huang Kuan-Hui

机构信息

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

出版信息

Fertil Steril. 2004 Jun;81(6):1642-9. doi: 10.1016/j.fertnstert.2003.11.034.

Abstract

OBJECTIVE

To determine the accuracy of differential diagnosis by team consultation of abortion in progression, low-lying implantation/cervicoisthmic pregnancy, and cervical pregnancy (CP) in patients referred for suspicion of abnormal implantation on the lower segment and cervix of the uterus and to determine the efficacy of endoscopic surgery with uterine artery blockade followed by cervical evacuation in the treatment of confirmed CP.

DESIGN

Prospective observational study under multiple-clinic and multiple-hospital cooperation.

SETTING

Tertiary clinical and academic medical center.

PATIENT(S): Twenty-seven women with a tentative diagnosis of CP made at their primary gynecologists' offices from July 1999 to June 2003.

INTERVENTION(S): Second-opinion ultrasound scanning with transabdominal and transvaginal approach and optional color Doppler use. For patients with confirmed CP, a new treatment modality with laparoscopy-assisted uterine artery ligation followed by hysteroscopic local endocervical resection to remove the ectopic pregnancy was employed. For patients with abortion in progression or low-lying implantation/cervicoisthmic pregnancy (non-CP) requiring termination, dilatation and curettage (D&C) was performed under transabdominal ultrasound guidance.

MAIN OUTCOME MEASURE(S): Fulfillment of ultrasound-based diagnostic criteria and operative course, convalescence, and commencement of menstruation in those patients with confirmed CP.

RESULT(S): Cervical pregnancy was diagnosed in six (22.2%) patients at <or=9-weeks' gestation, and they were all successfully treated without the need for adjuvant therapy. The mean operating time was 119 minutes, and the mean blood loss was 125 mL. Menstruation began a mean of 63 days after the treatment. Termination of non-CPs was achieved by a simple D&C.

CONCLUSION(S): Team consultation minimizes false-positive ultrasound-based diagnosis of CP. A single-step combination endoscopic operation is an effective uterus-preserving alternative in the management of CP.

摘要

目的

确定因怀疑子宫下段和宫颈植入异常而转诊的患者中,通过团队会诊对难免流产、低置胎盘/宫颈峡部妊娠和宫颈妊娠(CP)进行鉴别诊断的准确性,并确定子宫动脉阻断后行宫颈排空的内镜手术在治疗确诊CP中的疗效。

设计

多诊所和多医院合作的前瞻性观察研究。

地点

三级临床和学术医疗中心。

患者

1999年7月至2003年6月在其初级妇科医生办公室初步诊断为CP的27名女性。

干预措施

采用经腹和经阴道途径的二次超声检查,并酌情使用彩色多普勒。对于确诊为CP的患者,采用一种新的治疗方式,即腹腔镜辅助子宫动脉结扎,随后行宫腔镜下宫颈局部切除术以清除异位妊娠。对于需要终止妊娠的难免流产或低置胎盘/宫颈峡部妊娠(非CP)患者,在经腹超声引导下进行刮宫术。

主要观察指标

确诊为CP的患者基于超声的诊断标准达成情况、手术过程、康复情况及月经恢复情况。

结果

6例(22.2%)妊娠≤9周的患者被诊断为宫颈妊娠,且均成功接受治疗,无需辅助治疗。平均手术时间为119分钟,平均失血量为125毫升。治疗后平均63天月经恢复。非CP患者通过简单刮宫术终止妊娠。

结论

团队会诊可最大限度减少基于超声的CP假阳性诊断。单步联合内镜手术是CP治疗中一种有效的保留子宫的替代方法。

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