血浆N端脑钠肽、峰值耗氧量及左心室射血分数与慢性心力衰竭严重程度的比较

Comparison of plasma N-brain natriuretic peptide, peak oxygen consumption, and left ventricular ejection fraction for severity of chronic heart failure.

作者信息

Williams Simon G, Ng Leong L, O'Brien Russell J, Taylor Steve, Li Yi-Fen, Tan Lip-Bun

机构信息

Academic Unit of Molecular Vascular Medicine, University of Leeds, Leeds General Infirmary, Leeds, United Kingdom.

出版信息

Am J Cardiol. 2004 Jun 15;93(12):1560-1. doi: 10.1016/j.amjcard.2004.03.014.

DOI:10.1016/j.amjcard.2004.03.014

PMID:15194038

Abstract

We investigated whether a simple blood test of plasma N-brain natriuretic peptide (N-BNP), compared with echocardiographic left ventricular ejection fraction (LVEF), both measured at rest, correlated well with aerobic exercise capacity (peak oxygen consumption [VO(2)]) in patients with chronic heart failure. Plasma N-BNP was found to significantly correlate with peak VO(2) (p <0.001) and exercise duration (p = 0.001), whereas LVEF showed very poor correlations with peak VO(2) and exercise duration (both p >0.3). The results suggest that N-BNP actually reflects functional cardiac impairment better than LVEF.

摘要

我们研究了在静息状态下测量的血浆N端脑钠肽（N-BNP）简单血液检测与超声心动图左心室射血分数（LVEF）相比，是否与慢性心力衰竭患者的有氧运动能力（峰值耗氧量[VO₂]）具有良好的相关性。结果发现，血浆N-BNP与峰值VO₂（p<0.001）和运动持续时间（p = 0.001）显著相关，而LVEF与峰值VO₂和运动持续时间的相关性非常差（两者p>0.3）。结果表明，N-BNP实际上比LVEF更能反映心脏功能损害。