卡波西肉瘤相关疱疹病毒末端重复序列的DNA复制需要潜伏相关核抗原1的有丝分裂染色体结合活性。
Mitotic chromosome-binding activity of latency-associated nuclear antigen 1 is required for DNA replication from terminal repeat sequence of Kaposi's sarcoma-associated herpesvirus.
作者信息
Lim Chunghun, Choi Changtaek, Choe Joonho
机构信息
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea.
出版信息
J Virol. 2004 Jul;78(13):7248-56. doi: 10.1128/JVI.78.13.7248-7256.2004.
Abstract
Latency-associated nuclear antigen 1 (LANA1) of Kaposi's sarcoma-associated herpesvirus (KSHV) is implicated in the persistence of the viral genome during latent infection. It has been suggested that LANA1 tethers the viral genome to the host chromosome and also participates actively in DNA replication from the terminal repeat of KSHV. Here we show by mutational analysis that the mitotic chromosome-binding activity of LANA1 is tightly coupled to its replication activity. Thus, KSHV appears to have evolved a unique tactic for its stable maintenance.
摘要
卡波西肉瘤相关疱疹病毒（KSHV）的潜伏相关核抗原1（LANA1）与潜伏感染期间病毒基因组的持续性有关。有人提出，LANA1将病毒基因组与宿主染色体相连，并积极参与KSHV末端重复序列的DNA复制。在这里，我们通过突变分析表明，LANA1的有丝分裂染色体结合活性与其复制活性紧密相关。因此，KSHV似乎已经进化出一种独特的策略来实现其稳定维持。
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