在一名患有慢性肉芽肿病的男孩中，卡泊芬净和脂质体两性霉素B联合治疗失败后，伏立康唑成功消除了侵袭性构巢曲霉肺部感染。
Successful elimination of an invasive Aspergillus nidulans lung infection by voriconazole after failure of a combination of caspofungin and liposomal amphotericin B in a boy with chronic granulomatous disease.
作者信息
Rösen-Wolff Angela, Koch Anne, Friedrich Wilhelm, Hahn Gabriele, Gahr Manfred, Roesler Joachim
机构信息
Department of Pediatrics, University Hospital Dresden, Dresden, Germany.
出版信息
Pediatr Infect Dis J. 2004 Jun;23(6):584-6. doi: 10.1097/01.inf.0000130741.01940.ff.
Abstract
Chronic granulomatous disease is an inherited defect in host defense mechanisms mainly affecting neutrophil function. Pulmonary infection with Aspergillus nidulans in a child with chronic granulomatous disease could not be eliminated by a combination of caspofungin and liposomal amphotericin B. Voriconazole was successful in clearing the infection.
摘要
慢性肉芽肿病是一种宿主防御机制的遗传性缺陷，主要影响中性粒细胞功能。一名患有慢性肉芽肿病的儿童发生烟曲霉肺部感染，卡泊芬净和两性霉素B脂质体联合治疗未能清除感染。伏立康唑成功清除了感染。
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