Akanmu Moses A, Songkram Chalermkiat, Kagechika Hiroyuki, Honda Kazuki
Department of Biosystem Regulation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, 101-0062, Japan.
Neurosci Lett. 2004 Jul 8;364(3):199-202. doi: 10.1016/j.neulet.2004.04.047.
The aim of this study was to evaluate, in comparison with melatonin (MLT), the effects of a novel 2-melatonin derivative, having a 2-trifluoromethyl group (MLTD) on the sleep-wake cycle in freely behaving rats. Doses of MLTD (100, 300 and 500 nmol/100 microl saline) or MLT (500 nmol/100 microl saline) replaced the i.c.v. infusion of saline during the diurnal infusion period (7:00-17:00). Diurnal infusion of MLTD significantly (P < 0.05) increased NREM sleep at doses of 300 and 500 nmol during the second 4-h time interval of the light period and the lowest dose showed delayed effects on NREM sleep in the third 4-h time interval. However, REM sleep was only increased significantly at the dose of 500 nmol. The infusion of MLT did not have effects on REM sleep but significantly increased NREM sleep. These findings support the notion that MLTD diurnal infusion into the third ventricle produces soporific effects dose-dependently and more potently than MLT. Thus, MLTD may play an important role in studies of sleep.
本研究的目的是与褪黑素（MLT）相比，评估一种新型的带有2-三氟甲基基团的2-褪黑素衍生物（MLTD）对自由活动大鼠睡眠-觉醒周期的影响。在白天输注期（7:00-17:00），用MLTD（100、300和500 nmol/100微升生理盐水）或MLT（500 nmol/100微升生理盐水）的剂量替代脑室内输注生理盐水。白天输注MLTD在光照期的第二个4小时时间段内，300和500 nmol剂量时显著（P<0.05）增加了非快速眼动睡眠，最低剂量在第三个4小时时间段对非快速眼动睡眠有延迟作用。然而，快速眼动睡眠仅在500 nmol剂量时显著增加。输注MLT对快速眼动睡眠无影响，但显著增加了非快速眼动睡眠。这些发现支持这样一种观点，即向第三脑室白天输注MLTD会产生剂量依赖性的催眠作用，且比MLT更有效。因此，MLTD可能在睡眠研究中发挥重要作用。
Zotero 插件