南非的家族性高胆固醇血症

Marais Adrian David, Firth Jean Catherine, Blom Dirk Jacobus

Lipidology Division of Internal Medicine and MRC Cape Heart Group, University of Cape Town Health Science Faculty, Observatory, South Africa.

Semin Vasc Med. 2004 Feb;4(1):93-5. doi: 10.1055/s-2004-822991.

South Africa, especially the Caucasian part of the population, has one of the highest incidences of familial hypercholesterolemia in the world. The founder effect in this region has led to this high incidence and to a limited number of mutations in the low-density lipoprotein-receptor gene. This chapter describes current situation concerning the management of familial hypercholesterolemia in South Africa.

南非，尤其是白人群体，是世界上家族性高胆固醇血症发病率最高的地区之一。该地区的奠基者效应导致了这种高发病率以及低密度脂蛋白受体基因中有限的突变数量。本章描述了南非家族性高胆固醇血症管理的现状。