槟榔相关颊部鳞状细胞癌预后评估的分子标志物。
The molecular markers for prognostic evaluation of areca-associated buccal squamous cell carcinoma.
作者信息
Liu Chung-Ji, Chang Kuo-Wei, Chao Shou-Yee, Kwan Po-Cheung, Chang Shun-Min, Yen Rui-Yin, Wang Chun-Yu, Wong Yong-Kie
机构信息
Department of Dentistry, Mackay Memorial Hospital, Taiwan, ROC.
出版信息
J Oral Pathol Med. 2004 Jul;33(6):327-34. doi: 10.1111/j.1600-0714.2004.00092.x.
BACKGROUND
Buccal squamous cell carcinoma (BSCC) is the most frequently occurring oral cancer in Asians due to the popularity of areca use in this area. The aim of the present study was to evaluate the survival of areca-associated BSCC associated with multiple molecular markers.
METHODS
Using immunohistochemistry, we evaluated the survival of a cohort of 55 patients with BSCC being followed long term, as correlated to the expression of variable markers.
RESULTS
We found that p53, p21, Rb, cyclin D1 (CCD1), MDM2, and gamma-catenin were positive in 81, 60, 70, 31, 88, and 44% of patients, respectively. Subjects with -ve immunoreactivity for CCD1, and +ve immunoreactivity for MDM2 and gamma-catenin had significantly better survival than subjects with the opposite immunoreactive pattern. KAPLAN-meier survival curves confirmed this association.
CONCLUSION
The data indicate that expression of CCD1, MDM2, and gamma-catenin might serve as potential prognostic markers for BSCC in areca-using patients.
背景
由于该地区槟榔的广泛使用，颊部鳞状细胞癌（BSCC）是亚洲人最常见的口腔癌。本研究的目的是评估与多种分子标志物相关的槟榔相关BSCC的生存率。
方法
我们采用免疫组织化学方法，评估了55例长期随访的BSCC患者队列的生存率，并将其与多种标志物的表达情况相关联。
结果
我们发现，p53、p21、Rb、细胞周期蛋白D1（CCD1）、MDM2和γ-连环蛋白的阳性表达率分别为81%、60%、70%、31%、88%和44%。CCD1免疫反应阴性、MDM2和γ-连环蛋白免疫反应阳性的患者生存率显著高于免疫反应模式相反的患者。KAPLAN-meier生存曲线证实了这种关联。
结论
数据表明，CCD1、MDM2和γ-连环蛋白的表达可能是槟榔使用者BSCC的潜在预后标志物。
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