Heil Sarah H, Alessi Sheila M, Lussier Jennifer Plebani, Badger Gary J, Higgins Stephen T
Department of Psychiatry, University of Vermont, Burlington, 05401-1419, USA.
Nicotine Tob Res. 2004 Jun;6(3):471-9. doi: 10.1080/14622200410001696619.
Significant positive associations between early and later abstinence are often reported in clinical trials on smoking cessation, but those relationships do not permit causal inferences. The present study was conducted to examine experimentally whether prior smoking abstinence histories can directly facilitate later abstinence, using a contingency management procedure to manipulate prior abstinence. A total of 40 adult cigarette smokers who were not trying to quit were randomly assigned to one of two conditions: Contingent ALL (C-ALL), who earned monetary incentives contingent on smoking abstinence during three 5 day experimental periods; or Contingent LAST (C-LAST), who earned incentives independent of abstinence during the first two periods (i.e., noncontingent payments) and contingent on abstinence during the final period. The contingency management procedure was effective in establishing different abstinence histories in the two conditions during the first two periods. Comparison of abstinence levels between the C-ALL and C-LAST conditions during the third period showed significantly greater abstinence in the C-ALL condition, although nicotine withdrawal and other subject ratings generally did not differ significantly between the two conditions. These results provide experimental evidence that prior abstinence histories can directly influence subsequent efforts to abstain from smoking.
在戒烟临床试验中,经常报告早期和后期戒烟之间存在显著的正相关,但这些关系不允许进行因果推断。本研究旨在通过实验检验既往戒烟史是否能直接促进后期戒烟,采用应急管理程序来操纵既往戒烟情况。共有40名未尝试戒烟的成年吸烟者被随机分配到两种条件之一:全期应急组(C-ALL),在三个5天的实验期内,根据戒烟情况获得金钱奖励;或最后一期应急组(C-LAST),在前两个时期获得与戒烟无关的奖励(即非应急支付),在最后一期根据戒烟情况获得奖励。在前两个时期,应急管理程序有效地在两种条件下建立了不同的戒烟史。在第三期,比较C-ALL组和C-LAST组的戒烟水平,结果显示C-ALL组的戒烟情况显著更好,尽管两组之间的尼古丁戒断和其他受试者评分一般没有显著差异。这些结果提供了实验证据,表明既往戒烟史可以直接影响后续的戒烟努力。