使用组蛋白去乙酰化酶抑制剂进行胎儿血红蛋白合成的药理学诱导。
Pharmacological induction of fetal hemoglobin synthesis using histone deacetylase inhibitors.
作者信息
Cao Hua
机构信息
Division of Medical Genetics, University of Washington, Seattle 98195, USA.
出版信息
Hematology. 2004 Jun;9(3):223-33. doi: 10.1080/10245330410001701512.
PMID:15204104
Abstract
A number of pharmacological agents are currently available for the induction of the fetal hemoglobin (Hb F) to treat the patients with sickle cell disease and beta-thalassemia. In the present review, we summarized the investigation and development of these Hb F-inducing agents and introduced histone deacetylase inhibitors as the new strategy to induce Hb F to treat the hemoglobin disorders
摘要
目前有多种药物可用于诱导胎儿血红蛋白（Hb F）生成，以治疗镰状细胞病和β地中海贫血患者。在本综述中，我们总结了这些诱导Hb F生成药物的研究与开发情况，并介绍了组蛋白去乙酰化酶抑制剂作为诱导Hb F生成以治疗血红蛋白病的新策略。
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