Nakamura Kunihide, Harasaki Hiroaki, Fukumura Fumio, Fukamachi Kiyotaka, Whalen Robert
Department of Biomedical Engineering & Applied Therapeutics, The Cleveland Clinic Foundation, Cleveland, OH, USA.
Scand Cardiovasc J. 2004 Mar;38(1):59-63. doi: 10.1080/14017430410024856.
The purpose of the present study was to evaluate the effects of pulsatile cardiopulmonary bypass (CPB) on sheep regional renal blood flow by comparing pulsatile and non-pulsatile perfusion at two different flow rates.
Seven female Suffolk sheep were used and the animals were perfused with pulsatile and non-pulsatile CPB at flow rates of 60 and 100 ml/min/kg. Regional renal blood flow was measured by the colored microsphere method. General linear model ANOVA was performed to analyze the data.
Regional renal blood flow was significantly higher in both outer and middle cortices of pulsatile CPB compared with non-pulsatile CPB (outer cortex: pulsatile CPB, 381+/-192 ml/min/100 g, non-pulsatile CPB, 255+/-151 ml/min/100g, p=0.002; middle cortex: pulsatile CPB, 239+/-114 ml/min/100 g, non-pulsatile CPB, 176+/-80 ml/min/100 g, p=0.02). The increase of flow rate from 60 to 100 ml/min/kg improved renal cortical blood flow significantly.
The regional renal blood flow was significantly higher in both outer and middle cortices of pulsatile CPB compared with the non-pulsatile CPB.
本研究的目的是通过比较两种不同流速下的搏动性体外循环（CPB）和非搏动性灌注，评估搏动性CPB对绵羊局部肾血流的影响。
使用7只雌性萨福克绵羊，以60和100毫升/分钟/千克的流速对动物进行搏动性和非搏动性CPB灌注。采用彩色微球法测量局部肾血流。进行一般线性模型方差分析以分析数据。
与非搏动性CPB相比，搏动性CPB的肾皮质外层和中层的局部肾血流均显著更高（外层皮质：搏动性CPB，381±192毫升/分钟/100克，非搏动性CPB，255±151毫升/分钟/100克，p = 0.002；中层皮质：搏动性CPB，239±114毫升/分钟/100克，非搏动性CPB，176±80毫升/分钟/100克，p = 0.02）。流速从60增加到100毫升/分钟/千克可显著改善肾皮质血流。
与非搏动性CPB相比，搏动性CPB肾皮质外层和中层的局部肾血流均显著更高。
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