通过发育程序控制消除纤毛虫草履虫种系序列实现大规模基因组重塑。

Large-scale genome remodelling by the developmentally programmed elimination of germ line sequences in the ciliate Paramecium.

作者信息

Bétermier Mireille

机构信息

CNRS UMR 8541, Laboratoire de Génétique Moléculaire, Ecole Normale Supérieure, 46 rue d'Ulm, 75005 Paris, France.

出版信息

Res Microbiol. 2004 Jun;155(5):399-408. doi: 10.1016/j.resmic.2004.01.017.

DOI:10.1016/j.resmic.2004.01.017

PMID:15207872

Abstract

In Paramecium, during the development of the somatic macronucleus, precise excision of thousands of single-copy non-coding sequences is initiated by specific DNA double-strand breaks, while imprecise elimination of germ-line-limited repeated sequences leads to internal deletions or chromosome fragmentation. Recent data point to a role of non-coding RNAs in the epigenetic programming of these rearrangements.

摘要

在草履虫中，在体细胞大核发育过程中，数千个单拷贝非编码序列的精确切除由特定的DNA双链断裂启动，而生殖系受限重复序列的不精确消除则导致内部缺失或染色体片段化。最近的数据表明非编码RNA在这些重排的表观遗传编程中发挥作用。