Gα/组织转谷氨酰胺酶2：信号转导中一种新出现的G蛋白

Ghalpha/tissue transglutaminase 2: an emerging G protein in signal transduction.

作者信息

Mhaouty-Kodja Sakina

机构信息

Institut Pasteur, Département de Biologie du Développement, URA-CNRS 2578. Paris Cedex 15, France.

出版信息

Biol Cell. 2004 Jun;96(5):363-7. doi: 10.1016/j.biolcel.2004.03.003.

DOI:10.1016/j.biolcel.2004.03.003

PMID:15207905

Abstract

Gh protein is an heterodimer made up of two subunits alpha and beta. Different from the traditional monomeric and heterotrimeric G proteins, Ghalpha subunit exhibits both GTPase and transglutaminase activities whereas Ghbeta was identified as calreticulin. Activation of Gh by G protein-coupled receptors (GPCR) turns off transglutaminase activity and shifts Ghalpha to signal transducer. Thereafter, Ghalpha regulates downstream effectors. All these aspects are discussed in the present review, in order to shed new light on this atypical G protein.

摘要

Gh蛋白是一种由α和β两个亚基组成的异源二聚体。与传统的单体和异源三聚体G蛋白不同，Ghalpha亚基兼具GTP酶和转谷氨酰胺酶活性，而Ghbeta被鉴定为钙网蛋白。G蛋白偶联受体（GPCR）对Gh的激活会关闭转谷氨酰胺酶活性，并使Ghalpha转变为信号转导器。此后，Ghalpha调节下游效应器。本综述讨论了所有这些方面，以便为这种非典型G蛋白提供新的见解。